57,899 total views, 8 views today
People often ask questions about which genotype is the best or the strongest in respect to malaria proneness. There is no direct answer to that since the genotypes have their advantages and disadvantages, take your time to read them below and decide for yourself.
Advantages and Benefits of Genotype AA
From our previous article on the various types of Genotype and blood groups here. We can deduce that Genotype AA has the uttermost advantage when it comes to choosing a partner for copulation and reproduction( read on choosing a life partner here). People with genotype AA can reproduce with any other genotypes with having the fear of having offspring with sickle cell disease also known as genotype SS.
Disadvantages and Cons of Genotype AA
The teaching hospital at the University of Uyo carried out a research on this topic. The research reinstated that people with AA genotype are more prone and susceptible to Falciparum Malaria (malaria parasite ). They screened some children with Malaria parasites and found that 93.3% of them are AA genotype. About just 5% of the children screened were of genotype AS. They found facts during the screening of blood group, haemoglobin genotypes and malaria parasite or M.P (falciparum malaria). This indicates that people with genotype AA has high Malaria Proneness. (The parent determines the blood group of a child. Read about it here)
Why People With Genotype AA have High Malaria Proneness
Various research from various medical fields in the past has established the fact that malaria parasites (falciparum malaria) gotten by mosquito bites have a very high rate of oxygen use and consumption. The malaria parasite has also been known to also consume massive amounts of haemoglobin, for survival and during the peripheral blood period/stage of replication and duplication.
Since blood genotype AA red blood cells contain normal haemoglobin both in quantity and structure, thereby resulting in more oxygen-binding capacity and fueling of the malaria parasite duplication and replication process. This is the major reason why the malaria parasite (falciparum malaria) survives and thrives well in the AA genotype compared to other genotypes thereby Increasing the Malaria proneness of people with the AA genotype.
Advantage and Benefits of Genotype AS
It was also realized during the research that, being of blood genotype AS (sickle cell carrier) bestows and confers on you some form of protection from malaria parasite (falciparum malaria). This is because of the complex lifecycle of the parasite. When a person of AS genotype is infected with the parasite, the presence of the parasite causes the red blood with defective haemoglobin to rupture prematurely. This makes the Plasmodium parasite to be unable to reproduce or replicate since they need large amounts of haemoglobin and oxygen to do so. These happen during the blood peripheral blood stage of replication.
Also, the polymerization of haemoglobin hinders and affect the ability of the malaria parasite(M.P) to digest it, In areas or regions prone to Malaria parasite or mosquitoes (West Africa, East Africa, India, e.t.c), People of genotype AS( sickle cell carrier ) have higher chances of survival than people of genotype AA. Genotype AS ( defective haemoglobin) red blood cells conform and adhere to the parasitized red cells more easily than red blood cells of genotype AA ( normal haemoglobin). Haemoglobin Electrophoresis can detect abnormal haemoglobin forms. Haemoglobin Electrophoresis is a form of gel electrophoresis in which different types of haemoglobin moves at different and varying speeds. The most common forms identified from the process are people with Genotype AS( sickle cell haemoglobin HBS) and Genotype SS( Sickling HBSC).
All these indicate that the Malaria proneness of people with genotype AS is than that of people with genotype AA.
Disadvantages and Cons of Genotype AS
Also from the initial article on knowing your genotype and blood group here, we can deduce the fact that people with AS genotype are at a great disadvantage when they want to choose who to reproduce or copulate with. the reason why is because they are sickle cell carriers and can only copulate with Genotype AA alone, this is to avoid them having offspring who will carry the dreaded and disadvantaged sickle cell disease genotype SS.
Disadvantages and Cons of Genotype SS
Even though people with genotype SS( sickle cell disease) has the defective haemoglobin advantage, the protective effect on malaria enjoyed by the people with genotype AS does not apply to them. The reason is that malaria is the most common cause of health crisis for SS patients in regions where the parasite is available. Genotype SS patients should take anti-malaria chemoprophylaxis treatment throughout their lifetime.
Malaria Chemoprophylaxis is the preventive treatment of malaria for people with sickle cell disease(SS genotype). Also, people who don’t have immunity against malaria travelling to a region prone to malaria also take this treatment. You can also read about other ways to prevent malaria here. You can also read more about sickle cell disease and how to manage its crises here. Now you know the advantages and disadvantages of each genotype, you should be able to decide which one is the strongest or best genotype by yourself. If you enjoy this article please drop a comment
If you find this article interesting, please “Like” and “Share” it on your social media by clicking below. Also, don’t forget to drop a comment. Thanks
My girlfriend is an AA and i’m an AS,are we compatible and are there any chances of giving birth to a sickle cell carrier(SS)?
***
Female: AA
Male:AS
NO!!!
it either AA or AS babies……
Good evening, I am AS by genotype also my partner we were about to get married b4 we discovered and we have did abortion severally, how many chances do we have if SS in our future children?
it best you both go your separate ways… what if the abortions you did one of them was AS.. it risky taking chances you know
you have plenty chances of SS in the future
I treat malaria almost every month but my genotype is AS, I’m confused
go for a genotype test again…
try going to the hospital for a proper check up, please dont just assume
I really appreciate bcs I understand everything I know need to know about the Genotype
I understanding about genotype just got skyrocket here
Thanks for the update
I have know what I want to know here, thanks
I really need to go to hospital to know my blood type becoz my wife to be is AS she told me to check my blood group, initially I really did not care for all these things but after reading through,I think is important to know my blood type, thanks though it was helpful
What you need to check is genotype not blood group.
Thanks for this
I learnt alot
Am always sick of malaria
Please is there a way to prevent it
Am tired of taking drugs
Try to always consume much water most especially hot water in the morning
Thanks. I got the knowledge. I can make a better decision now.
I’ve known what I wanted to know thank you
Very interesting Information.
Thanks,it was helpful to me.
Very informative thanks for sharing
What happens when an AS genotype gets malaria?
What happens when an as genotype get malaria
Thank you for the explanation
Thank you for this well explained information .
informative
I don’t think so … you can reply me 330-368-6176
Wow!!
This is awesome I really learn alot.
Thanks so much, it is an eye opener
Am AA but I hardly fell sick or fever
Why do one often fall sick of malaria even though being of AS genotype?
Yes I don’t easily fall sick of malaria but if i eventually do i will be in big trouble cos it take me week to recover.
Can two AS people marry then use a prevention for them not to give birth to SS
I don’t think so because it complicated
How many SS can be produced if AS marry AS?
Good read
I really appreciate this
But had like to ask one question hope to hear from you soon. Am AA I hardly fall sick, but when I do have malaria it’s come with full force and serious. Is there any reason to it?
Thanks
..thanks for your article I have learnt a lot. Am AA but I rarely fall sick
of malaria , for more than 3years I don’t take malaria drug and I don’t feel the symptoms at all.
you might need to checkyour genotype else you a special one
Thanks for this article. It’s really be awesome more of genotype
Thanks in a million
Can AS marry SS
Hey i amnot a specialist but have more knowledge to say no because the problem is in the s and you are more prone to have SS kids who will end up suffering. You have higher chances to have more SS than S
I just did only one test and the result is AS, plz can I go for another test?
Can as & ss marry together?
there is every tendency you may give birth to sickle cell child (SS)……
Thanks alot for this wonderful explanation..much love
Wow! This is great i learnt something different today
Well! this was really great but having know all of this, but i am always suffering from fever please how can this be reduce.
Is it possible to get genotype result same day the test is been done? If yes can the result be accurate?
I have my correct answer to my question, to me AA is more advantageous or much more far better than any other genotype since malaria can fight with all the genotype
Wow! I knew nothing about genotypes . I just did mine .Reading through the result I could not understand what it means. Thanks to this article .I don’t need to see the doctor for explanations.
I check my genotype and the result is SS but i don’t have any symptoms of SS. Is it possible for me to be SS without having the symptoms
Please i need answer to this
Go and another test, don’t rely on just a single test
Go for another test, don’t rely on just one test please ***
Nice one…
I have treated malaria not less four times just this year..
Gosh! Am tired
Can As and AA give birth to AA
It is possible
I think the chance is 75% for AA + AS. Each “A” carrying a 25% weight in the combinations.
A = 25%
A = 25%
A = 25%
S = 25%
3x “A” = 75% chance of AA
1x “S” = 25% chance the child becomes a carrier.
Yes
Yes
I possessed a Genotype call AA, and my girlfriend possessed a Genotype of SS what do you for our relationship?
Genotype AA can marry any of the other genotypes so yes you can be with her but you have to get prepared financially to take good care of her because of her SS condition.
Can As marry As
Advice No !
I’m AS and I impregnant a girl and she is also AS what should I do
Waooow! What a well explanatory Article.
I do treat malaria Everytime mosquito bites me and I went for a blood Genotype test the results shows that am AS Genotype is it possible for an AS Genotype to suffer malaria Everytime I am thinking the result is not correct I want to go for another genotype test for confirmation
I think u should run another test somewhere else,I was told the test should be done like three times in different hospital,the two that correspond out of the three is ur real genotype
What are the chances of a man with AA marrying a woman AS? Can they by any chance produce SS child?
No they can marry each other and have healthy children because they are compatible
So explanatory, thanks so much…
how can i know my genotype without going to the hospital
It’s only hospital can determine that
How can someone know is genotype without going to hospital
Please, I’m AS & my proposal is neither AS. And also we have a good relationship which now some weeks left for us to get marriage. Please am need for your medical advice.
Secondly, can someone be Blood group A & Rhesus Factor positive grow fat upon all exercise & fatiks still be growing fats, i need some advice
Very clear and understanding, how can be getting more tips on my blood group & genes, please message me on +233 594903018
GOOD ONE
Can as genotype be able to fat is there any chance or possibility for as genotype to get fat
Type here..i have what i wanted
What pls
At least you have enlighten me more thanks
Wao!
Yoooooo this is so great it tearch all about life and having a conpatibiloty in to coples
Perfectly said
Very understanding,I got the knowledge that I was looking for. Thank you.
Thanks this helped me a lot I have gotten all the information I needed
So interesting
It’s interesting
Very understanding